Coagulation factor XIII (FXIII) is a transglutaminase involved in coagulation and fibrinolysis. In plasma, FXIII circulates at a concentration of about 21 μg/ml [] as a ; doi/physrev—Factor XIII (FXIII) is unique among clot-ting factors for a number of reasons: 1) it is a protransglutaminase, which becomes activated in the last stage of coagulation; 2) it works on an insoluble substrate; 3) its potentiallyactivesubunitisalsopresentinthecytoplasmofplatelets,monocytes,monocyte Calcium and catalysis. Calcium ions are required for the activation of plasma factor XIII after thrombin cleavage. 44, 45 There is a calcium-dependent conformational The fibrin stabilizing factor or coagulation factor XIII (FXIII) is a heterotetrameric protein complex, circulating in the plasma as a KDa molecule Factor XIII (FXIII) is unique among clotting factors for a number of reasons: 1) it is a protransglutaminase, which becomes activated in the last stage of coagulation; 2) it works on an insoluble substrate; 3) its potentially active subunit is also present in the cytoplasm of platelets, monocytes, monocyte-derived macrophages, dendritic
Coagulation Factor XIIIa Substrates in Human Plasma
Factor XIII activity 60 U/bag (+/− 30) U/bag (+/− 77) Factor XIII antigen mg/bag (+/− ) mg/bag (+/− ) Factor VIII U/bag (+/− ) Factor XIII (FXIII) is unique among clotting factors for a number of reasons: 1) it is a protransglutaminase, which becomes activated in the last stage of coagulation; 2) it Coagulation factor XIII (FXIII) is a stepchild among clotting factors. As opposed to all other zymogenic clotting factors, it is not the precursor of a proteolytic enzyme but of a
Factor XIII: A Coagulation Factor With Multiple …
; doi/physrev—Factor XIII (FXIII) is unique among clot-ting factors for a number of reasons: 1) it is a protransglutaminase, which becomes activated Factor XIII. Both FFP and cryoprecipitate contain coagulation factor XIII, and either can be used to treat severe factor XIII deficiency. A pharmaceutical form of factor XIII is